Nguyen Hoang Tung, Nguyen Thanh Trung, Ly Anh Tu


SIRT (Selective Internal Radiation Therapy)for liver cancer therapy
is a method in which a dose of radiation was delivered millions of microspheres
SIR-Spheres Ytrium-90 directly to liver tumors via hepatic
artery.In this treatment, millions of tiny radioactive beads are injected
directly into the arteries that supply blood to the tumour. These beads
will stay in the blood vessels around the tumours. This allows a very
strong radiation to reach the tumours directly. There is a very little
effect on healthy parts of the liver or other tissues in the area such as intestines
or skin.The treatment dose was limited less than the Maximum
Treatment Activity (MTA) in order that the absorbed doses were not
greater than the tolerances of normal liver (30Gy), of lungs (12Gy) and
of bone marrow (1.5Gy)[1]. Clinical experiences gave the result: when
combining with chemotherapy, radioactive microspheres can reduce the
size of tumours better than using chemotherapy only. It can help to
improve the quality of life and prolong the life of patients. For a large 

number of patients, this treatment can also help to shrink tumours which
can be removed later by surgery.


A.K. Padhy, 2004,”Radionuclice treatment of liver cancer”, SNM.

Anderson, J. H., Goldberg, J. A., Bessent, R. G., Kerr, D. J., McKillop, J. H., Stewart,

I., Cooke, T. G., & McArdle, C. S. 1992, ”Glass yttrium-90 microspheres for patients

with colorectal liver metastases”, Radiotherapy and Oncology, vol. 25, no. 2.

Blanchard, R. J. W. 1983, ”Treatment of liver tumours with yttrium-90 microspheres”,

Canadian Journal of Surgery, vol. 26, no. 5.

SIRTEX MEDICAL Inc, 2005, ”Training Program Physicians and institutions”, Sirtex

Medical Training Manual.

Bilbao, Jos Ignacio, Reiser, Maximilian F (Eds.), 2014, ”Liver Radioembolization with

Y Microspheres”, Second Edition.

Nijsen, J. F. W., het Schip, A. D., Hennink, W. E., Rook, D. W., van Rijk, P. P.,

& de Klerk, J. M. H. 2002, ”Advances in nuclear oncology: Microspheres for internal

radionuclide therapy in liver tumours”, Current Medicinal Chemistry, vol. 9, no. 1.

Campbell, A. M., Bailey, I. H., & Burton, M. A. 2001, ”Tumourdosimetry in human liver

following hepatic yttrium-90microsphere therapy”, Physics in Medicine and Biology, vol.

, no. 2.


  • There are currently no refbacks.