HYPOLIPIDEMIC EFFECT OF POLYSACCHARIDE EXTRACTED FROM AURICULARIA NIGRICANS ON TRITON WR-1339-INDUCED HYPERLIPIDEMIC MICE

Abstract

Auricularia nigricans is a medicinal mushroom - one of the most cultivated mushrooms due to its high nutritive and medicinal values. The
objective of this study was to evaluate the effect of the polysaccharides extracted from Auricularia nigricans in Triton WR-1339- induced hyperlipidemic mice. In order to meet the objective of the research, Triton WR-1339 was intraperitoneally injected at the dose of 400 mg/kg. At the same time, Auricularia nigricans polysaccharides (Auricula PSP) were orally administeredat the doses of 0.87 g/kg and 1.74 g/kg according to the treatment or pretreatment protocol. Atorvastatin (75 mg/kg) was used as the reference drug. The plasma triglycerides, total cholesterol, low-density
lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL) - cholesterol were determined by commercial kits. Preliminary results showed that the oral administration of Auricularia nigricans polysaccharides (Auricula PSP) made reduce the plasma