EXOSOME THERAPY: CURRENT PROGRESS OF CARGO-LOADED EXOSOMES IN CLINICAL APPLICATIONS

Abstract

Exosomes are nano vesicles released from cells that are structurally suitable for loading certain specific therapeutic potential compounds that have specific therapeutic effects in the target disease. Exosomal cargo may vary in response to different physiological or pathological conditions. Depending on the cargo characteristics, we have different ways of cargo loading and enhancing of targeting capacity on exosomes platform for drug deliver purpose. To date, there were a few initial practical applications in clinical practice on several fields, mainly applied in the fields of oncology and neurology. Here, we review the latest progress of exosomal cargo-loading biotechnology for therapeutic purposes. We also present current exosome engineering strategies for optimal clinical safety and efficacy