RESEARCH ON THE PREPARATION OF RAPID RELEASE PARACETAMOL 325 MG TABLETS

Abstract

Paracetamol is an active ingredient that has been researched and widely used for a long time because of its effectiveness and safety. However, with conventional tablet forms, the active ingredient is usually released 30-45 minutes after taking the pill. This study was conducted with the aim of formulating and preparing rapid release paracetamol tablets which can release the active ingredient almost completely within 10 minutes from the time of drug administration into the gastrointestinal tract. Paracetamol 325 mg rapid release tablets are prepared by wet granulation method using common excipients for tablets such as: Amidon, Avicel PH101, lactose, polyvinyl pirolidone K30 (PVP K30), talc, magnesium stearate, and super-dissolving excipients sodium bicarbonate.

Semi-finished granules are tested for several criteria such as moisture, flow rate, apparent density Pressing 500 mg tablets using an 8-punches rotary tablet press with 10mm punches and dies. The results showed that the tablets were prepared according to the formulation F1 including paracetamol 325 mg; sodium bicarbonate 65 mg; Amidon 95 mg; PVP K30 15 mg; slippery excipients talc and magnesium stearate (1:1) at the ratio of 2% for the best survey criteria. Finished tablets have good drug release ability (over 90% of paracetamol dissolves after 10 minutes). The results of the study open the prospect of preparing and manufacturing paracetamol 325 mg rapid-release tablets.