RESEACH ON THE PREPARATION OF QUICK-RELEASE ACYCLOVIR 200MG TABLETS WITH SODIUM CROSCAMELOSE EXCIPIENT

Abstract

Acyclovir is a potent and low-toxic antiviral drug used in the treatment of infections mainly caused by Herpes simplex and Varicella Zoster viruses. Although using the drug orally is convenient and easy to use, the drug has the disadvantage of low bioavailability because acyclovir is mainly absorbed at the end of the stomach and the beginning of the small intestine. Therefore, research was conducted to develop a formulation for rapid gastric release of Acyclovir 200 mg tablets. Tablets are prepared by wet granulation method, using excipients Amidon, Avicel PH101, lactose, polyvinyl pirolidone K30 (PVP K30), talc, magnesium stearate and soluble excipient sodium croscarmellose. Semi-finished granules are evaluated for moisture content, apparent density and flowability. Acyclovir 200 mg rapid release tablets are prepared from semi-finished granules using an 8-punch rotary tablet press and are evaluated for a number of quality criteria such as hardness, abrasion, mass uniformity, and dosage. active ingredients, disintegration and ability to control release of active ingredients. Research has developed a formula for preparing quick-release acyclovir 200 mg tablets that can disintegrate in a 0.1 N HCl environment in under 300 seconds with the amount of active ingredient released reaching 92.68% at 5 minutes.