THE IMPACT OF TAMANU OIL (Calophyllum inophyllum L.) ON IMPROVING THE WOUND HEALING PROCESS IN DIABETIC MICE MODEL

Abstract

Diabetic ulcers pose a significant challenge in clinical practice due to impaired wound healing caused by hyperglycemia, infections, and oxidative stress. This study evaluates the effects of Tamanu oil (Calophyllum inophyllum L.) from Hue City on wound healing in a diabetic mouse model. Chemical analysis revealed that Tamanu oil contains bioactive compounds, including calophyllolid and hexadecanoic acid, with antioxidant, anti-inflammatory, and antibacterial properties. In vitro experiments demonstrated that Tamanu oil stimulates fibroblast proliferation and exhibits antibacterial activity. In vivo studies on diabetic mice showed faster wound closure and earlier hair regrowth compared to the control group, suggesting that Tamanu oil supports diabetic wound healing.